Long-term persistence of hormonal adaptations to weight loss

P Sumithran; LA Prendergast; E Delbridge; K Purcell; A Shulkes; A Kriketos; J Proietto

Journal article

Long-term persistence of hormonal adaptations to weight loss

P Sumithran, LA Prendergast, E Delbridge, K Purcell, A Shulkes, A Kriketos, J Proietto

New England Journal of Medicine | Published : 2011

DOI: 10.1056/NEJMoa1105816

Abstract

BACKGROUND: After weight loss, changes in the circulating levels of several peripheral hormones involved in the homeostatic regulation of body weight occur. Whether these changes are transient or persist over time may be important for an understanding of the reasons behind the high rate of weight regain after diet-induced weight loss. METHODS: We enrolled 50 overweight or obese patients without diabetes in a 10-week weight-loss program for which a very-low-energy diet was prescribed. At baseline (before weight loss), at 10 weeks (after program completion), and at 62 weeks, we examined circulating levels of leptin, ghrelin, peptide YY, gastric inhibitory polypeptide, glucagon-like peptide 1, ..

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University of Melbourne Researchers

Priya Sumithran Author

Arthur Shulkes Author

Joseph Proietto Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

Supported by a project grant from the National Health and Medical Research Council (508920), a scholarship from the Endocrine Society of Australia, a Shields Research Scholarship from the Royal Australasian College of Physicians (to Dr. Sumithran), and funding from the Sir Edward Dunlop Medical Research Foundation (to Dr. Proietto).